66. Hill L, Ouhtit A, Loughlin SM, et al. Fas ligand: a sensor for DNA damage critical in skin cancer etiology. Science 1999; 285: 898-900. PubMed
67. Leverkus M., Yaar M, Gilchrest B. Fas/Fas ligand interaction contributes to UV-induced apoptosis in human keratinocytes. Exp. Cell. Res 1997; 232: 255-262. PubMed
68. Aragane, Y. IL-12 is expressed and released by human keratinocytes and epidermoid carcinoma cell lines. J. Immunol 1994; 153: 5366-5372 PubMed
69. Schwarz A, Maeda A, Kernebeck K, et al. Prevention of UV radiation-induced immunosuppression by IL-12 is dependent on DNA repair. J Exp Med 2005; 201(2): 173-9. PubMed
70. Gloster H, Brodland DG. The epidemiology of skin cancer. Dermatol. Surg 1996; 22: 217-226. PubMed
71. Schwarz A, Stander S, Berneburg M, et al. Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair. Nat Cell Biol 2002; 4: 26-31. PubMed
72. Nishigori C, Yarosh DB, Ullrich SE, et al. Evidence that DNA damage triggers interleukin 10 cytokine production in UV-irradiated murine keratinocytes. Proc. Natl Acad. Sci. USA 1996; 93: 10354-10359. PubMed
73. Qian C, Liu XY, Prieto J. Therapy of cancer by cytokines mediated by gene therapy approach. Cell Res. 2006; 16: 182-8. PubMed
74. Dees EC, Orlowski RZ. Targeting the ubiquitin-proteasome pathway in breast cancer therapy. Future Oncol 2006; 2(1): 121-35. PubMed
75. McBride WH, Iwamoto KS, Syljuasen R, et al. The role of the ubiquitin/proteasome system in cellular responses to radiation. Oncogene 2003; 22(37): 5755-73. PubMed
76. Lommel L, Ortolan T, Chen L, et al. Proteolysis of a nucleotide excision repair protein by the 26 S proteasome. Curr. Genet 2002; 42: 9-20. PubMed
77. Gillette TG, Yu S, Zhou Z, et al. Distinct functions of the ubiquitin-proteasome pathway influence nucleotide excision repair. EMBO J. 2006; 25:2529-38. PubMed
78. Sheng Y, Li L, Holmgren K, Pero RW. DNA repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer study. Phytomedicine 2001; 8 (4): 275-282. PubMed
79. Sheng Y, Pero RW, Amiri A, Bryngelsson C. Induction of apoptosis and inhibition of proliferation and clonogenic growth of human leukemic cell lines treated with aqueous extracts of Uncaria tomentosa. Anticancer Research 1998; 18: 3363-3368. PubMed
80. Mammone T, Akesson C, Gan D, Giampapa V, Pero RW. A water soluble extract from Uncaria tomentosa (cat's claw) is a potent enhancer of DNA repair in primary organ cultures of human skin. Phytotherapy Research 2006; 20: 178-183. PubMed
81. Middelkamp-Hup MA, Pathak MA, Parrado C, Goukassian D, Rius-Diaz F, Mihm MC, Fitzpatrick TB, Gonzalez S. Oral Polypodium leucotomos extract decreases ultraviolet-induced damage of human skin. J Am Acad Dermatol. 2004; 51:910-8. PubMed
82. Spencer JM, Nestor MS, Rigel DS. Oral Photoprotection-a new concept in UV photoprotection. Cosmetic Dermatology 2006; 19(5): 53. PubMed
83. Gonzalez S, Pathak J, Cuevas J, et al. Topical and oral administration with the extract of Polypodium leucotomos prevents acute sunburn and psoralen-induced phototoxic reactions as well as depletion of Lengerhans cells in human skin, Photodermatol Photoimmunol Photomed 1997; 13: 50-60. PubMed
84. Gonzalez S, Pathak MA. Inhibition of Ultraviolet-induced formation of reactive oxygen species, lipid peroxidation, erythema skin photosensitization by Polypodium leucotomos. Photodermatol Photoimmunol Photomed 1996; 12: 45-46. PubMed
85. Doshi R, Preston BD. Effect of oxidative exonuclease damage in the fidelity of T7 DNA polymerase. Proc Am Assoc Cancer Res 1990; 31: 100.
86. Chen W, Barthelman A, Martinez J, et al. Inhibition of cyclobutane pyrimidine dimer formation in epidermal p53 gene of UV-irradiated mice by alpha-tocopherol. Nutr Cancer 1997; 29: 205-211. PubMed
87. Middelkamp-Hup MA, Pathak MA, Parrado C, Garcia-Caballero T, Rius-Diaz F, Fitzpatrick TB, Gonzalez S. Orally administered Polypodium leucotomos extract decreases psoralen-UVA-induced phototoxicity, pigmentation, and damage of human skin. J Am Acad Dermatol. 2004; 50:41-9. PubMed
88. Scheinfeld N. Preliminary assessment of AC-11, an aqueous extract of uncaria tomentosa (cats claw), as an agent enhancing DNA repair in humans (P300) Poster presented at: Academy 06'; July 26-30, 2006; San Diego, Calif.
89. Scheinfeld NS. DNA Repair Adjuvants. ,Emanuel, Patrick; Scheinfeld, Noah; durki=77549]
66. Hill L, Ouhtit A, Loughlin SM, et al. Fas ligand: a sensor for DNA damage critical in skin cancer etiology. Science 1999; 285: 898-900. PubMed
67. Leverkus M., Yaar M, Gilchrest B. Fas/Fas ligand interaction contributes to UV-induced apoptosis in human keratinocytes. Exp. Cell. Res 1997; 232: 255-262. PubMed
68. Aragane, Y. IL-12 is expressed and released by human keratinocytes and epidermoid carcinoma cell lines. J. Immunol 1994; 153: 5366-5372 PubMed
69. Schwarz A, Maeda A, Kernebeck K, et al. Prevention of UV radiation-induced immunosuppression by IL-12 is dependent on DNA repair. J Exp Med 2005; 201(2): 173-9. PubMed
70. Gloster H, Brodland DG. The epidemiology of skin cancer. Dermatol. Surg 1996; 22: 217-226. PubMed
71. Schwarz A, Stander S, Berneburg M, et al. Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair. Nat Cell Biol 2002; 4: 26-31. PubMed
72. Nishigori C, Yarosh DB, Ullrich SE, et al. Evidence that DNA damage triggers interleukin 10 cytokine production in UV-irradiated murine keratinocytes. Proc. Natl Acad. Sci. USA 1996; 93: 10354-10359. PubMed
73. Qian C, Liu XY, Prieto J. Therapy of cancer by cytokines mediated by gene therapy approach. Cell Res. 2006; 16: 182-8. PubMed
74. Dees EC, Orlowski RZ. Targeting the ubiquitin-proteasome pathway in breast cancer therapy. Future Oncol 2006; 2(1): 121-35. PubMed
75. McBride WH, Iwamoto KS, Syljuasen R, et al. The role of the ubiquitin/proteasome system in cellular responses to radiation. Oncogene 2003; 22(37): 5755-73. PubMed
76. Lommel L, Ortolan T, Chen L, et al. Proteolysis of a nucleotide excision repair protein by the 26 S proteasome. Curr. Genet 2002; 42: 9-20. PubMed
77. Gillette TG, Yu S, Zhou Z, et al. Distinct functions of the ubiquitin-proteasome pathway influence nucleotide excision repair. EMBO J. 2006; 25:2529-38. PubMed
78. Sheng Y, Li L, Holmgren K, Pero RW. DNA repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer study. Phytomedicine 2001; 8 (4): 275-282. PubMed
79. Sheng Y, Pero RW, Amiri A, Bryngelsson C. Induction of apoptosis and inhibition of proliferation and clonogenic growth of human leukemic cell lines treated with aqueous extracts of Uncaria tomentosa. Anticancer Research 1998; 18: 3363-3368. PubMed
80. Mammone T, Akesson C, Gan D, Giampapa V, Pero RW. A water soluble extract from Uncaria tomentosa (cat's claw) is a potent enhancer of DNA repair in primary organ cultures of human skin. Phytotherapy Research 2006; 20: 178-183. PubMed
81. Middelkamp-Hup MA, Pathak MA, Parrado C, Goukassian D, Rius-Diaz F, Mihm MC, Fitzpatrick TB, Gonzalez S. Oral Polypodium leucotomos extract decreases ultraviolet-induced damage of human skin. J Am Acad Dermatol. 2004; 51:910-8. PubMed
82. Spencer JM, Nestor MS, Rigel DS. Oral Photoprotection-a new concept in UV photoprotection. Cosmetic Dermatology 2006; 19(5): 53. PubMed
83. Gonzalez S, Pathak J, Cuevas J, et al. Topical and oral administration with the extract of Polypodium leucotomos prevents acute sunburn and psoralen-induced phototoxic reactions as well as depletion of Lengerhans cells in human skin, Photodermatol Photoimmunol Photomed 1997; 13: 50-60. PubMed
84. Gonzalez S, Pathak MA. Inhibition of Ultraviolet-induced formation of reactive oxygen species, lipid peroxidation, erythema skin photosensitization by Polypodium leucotomos. Photodermatol Photoimmunol Photomed 1996; 12: 45-46. PubMed
85. Doshi R, Preston BD. Effect of oxidative exonuclease damage in the fidelity of T7 DNA polymerase. Proc Am Assoc Cancer Res 1990; 31: 100.
86. Chen W, Barthelman A, Martinez J, et al. Inhibition of cyclobutane pyrimidine dimer formation in epidermal p53 gene of UV-irradiated mice by alpha-tocopherol. Nutr Cancer 1997; 29: 205-211. PubMed
87. Middelkamp-Hup MA, Pathak MA, Parrado C, Garcia-Caballero T, Rius-Diaz F, Fitzpatrick TB, Gonzalez S. Orally administered Polypodium leucotomos extract decreases psoralen-UVA-induced phototoxicity, pigmentation, and damage of human skin. J Am Acad Dermatol. 2004; 50:41-9. PubMed
88. Scheinfeld N. Preliminary assessment of AC-11, an aqueous extract of uncaria tomentosa (cats claw), as an agent enhancing DNA repair in humans (P300) Poster presented at: Academy 06'; July 26-30, 2006; San Diego, Calif.
89. Scheinfeld NS. DNA Repair Adjuvants. Skin & Aging 2006:14(2); 72-6.
